Biotech, Fetal Cells, Medicine & Your Food

Science - PharmakeiaInformation moves or disappears on the internet every day, making it difficult or impossible to find. This information is provided so that you can make an informed decision. The information presented may be copyrighted, but is stored online for educational and reference purposes. (Hazards of Vaccines & Medication)

DNA – HEK Human Cell Line – original paper (pdf)

Mechanism of Sweet Taste Enhancers – Research (pdf)

The Ethics of HEK 293 (pdf)

Biotech Sweet Taste Enhancers (pdf)

Biotech & the Fear Factor (pdf)

Artificial Sweeteners- The Challenges of Tricking the Taste Buds (pdf)

Tricking the Tongue: How Biotech Might Let Us Cut the Sugar & Salt, But Keep the Taste (pdf)

Choosing a Sugar Substitute (pdf)

Fetal Cell Line Products (pdf)

Unethical Vaccines & Alternatives (pdf)

Vaccines Using Aborted Fetal Tissue (pdf)

FDA (US) Fetal Cell Line Meeting (pdf)

PepsiCo: We’ll reinvent the North American cola category – 4192013 (png)
PepsiCo and Senomyx Enter Into Collaboration to Discover Develop and Commercialize (pdf)
Perc6 2012 Update (png)
Pepsi Stops Using Aborted Fetal Cell Lines to Test Flavors (pdf)
Senomyx Corporate Profile (Wall Street) (png)
Senomyx Fact Sheet, June 1, 2011 (pdf)
Senomyx Fact Sheet – August 1, 2013 (pdf)
Senomyx Fact Sheet – January 2, 2014 (pdf)
Senomyx News Summaries (2008-2014) (png)
Senomyx Biotech Flavor Programs (2014) (png)
Senomyx Corporate Collaborations (2014) (png)
Senomyx Direct Sales Programs (2014) (png)
Senomyx News Updates – (png)
(2008) (2009) (2010) (2011) (2012) (2013-2014)

The World of Biotech –
Scientific Research Publications
Servant, G., Tachdjian, C and Li, X. (2010) Small Molecule Modulators of Family-C Taste GPCRs. In Igaku No Ayumi (Journal of Clinical and Experimental Medicine) volume 233 No. 9. Editor: Iiri, T. Ishiyaku Pub pp 881-891.
Zhang, F., Klebansky, B., Fine, R.M., Xu, H., Pronin, A., Liu, H., Tachdjian, C., and Li, X. (2008) Molecular mechanism for the umami taste synergism. Proc. Natl. Acad. Sci. USA. 106:52:20930–20934.
Pronin, A.N., Xu, H., Tang, H., Zhang, L., Li, Q., and Li, X. (2007). Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin. Current Biology. 17:16:1403-1408.
Pronin, A.N., Tang, H., Connor, J., and Keung, W. (2004). Identification of ligands for two human bitter T2R receptors. Chem Senses. 29:583-593.
Xu, H., Staszewski, L., Tang, H., Adler, E., Zoller, M., and Li, X. (2004). Different functional roles of T1R subunits in the heteromeric taste receptors. Proc. Natl. Acad. Sci. USA, 101:14258-14263.
Li, X., Staszewski, L., Xu, H., Durick, K., Zoller, M., Adler, E. (2002). Human receptors for sweet and umami taste. Proc. Natl. Acad. Sci. U.S.A. 99, 4692-4696.
Ozeck, M., Brust, P., Xu, H., and Servant, G. (2004) Receptors for bitter, sweet and umami taste couple to inhibitory G protein signaling pathways. Eur J Pharmacol. 489:139-149.
Pronin, A.N., Tang, H., Connor, J., and Keung, W. (2004). Identification of ligands for two human bitter T2R receptors. Chem Senses. 29:583-593.
Lu, M., Staszewski, L., Echeverri, F., Xu, H., and Moyer, B.D. (2004). Endoplasmic reticulum degradation impedes olfactory G-protein coupled receptor functional expression. BMC Cell Biol. 5:34-44
Lu, M., Echeverri, F., and Moyer, B.D. (2003) Endoplasmic reticulum retention, degradation, and aggregation of olfactory G-protein coupled receptors. Traffic, 4:416-433.
Zozulya, S., Echeverri, F., Nguyen, T. (2001) The human olfactory receptor repertoire. Genome Biol. 2:RESEARCH0018.
Selected Research by Senomyx Scientific Advisory Board

Tsien, R.Y. (1989) Fluorescent probes of cell signaling. Annu. Rev. Neurosci. 12, 227-253
Hoon, M.A., Adler, E., Lindemeier, J., Battey, J.F., Ryba, N.J., Zuker, C.S. (1999). Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity. Cell 96, 541-51.
Adler, E., Hoon, M.A., Mueller, K.L., Chandrashekar, J., Ryba, N.J., Zuker, C.S. (2000). A novel family of mammalian taste receptors. Cell 100, 693-702.
Chandrashekar, J., Mueller, K.L., Hoon, M,A., Adler, E., Feng, L., Guo, W., Zuker, C.S., Ryba, N.J. (2000). T2Rs function as bitter taste receptors. Cell 100, 703-711.
Nelson, G., Hoon, M.A., Chandrashekar, J., Zhang, Y., Ryba, N.J., Zuker, C.S. (2001). Mammalian sweet taste receptors. Cell 106, 381-90.
Nelson, G., Chandrashekar, J., Hoon, M.A., Feng, L., Zhao, G., Ryba, N.J., Zuker, C.S. (2002). An amino-acid taste receptor. Nature 416, 199-202.
Zhang, Y., Hoon, M.A., Chandrashekar, J., Mueller, K.L., Cook, B., Wu, D., Zuker, C.S., Ryba, N.J. (2003). Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell 112, 293-301.
Zhao, G.Q., Zhang, Y., Hoon, M.A., Chandrashekar, J., Erlenbach, I., Ryba, N.J., Zuker, C.S. (2003). The receptors for mammalian sweet and umami taste. Cell 115, 255-66.
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